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Although genetic factors are important in determining both the propensity to atopic disease and the specificity of the response to protein epitopes, the short period during which the increases in asthma and other allergic diseases have occurred suggests that environmental influences have been mainly responsible. For example, secular trends in the Finnish armed forces show a 20-fold increase in asthma among 18 year old recruits during the past 30 years.4
Further evidence of important
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