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Charles Shepherd has written guidelines on the care of patients with myalgic encephalomyelitis and the postviral fatigue syndrome in his capacity as medical adviser to the ME Association. The second edition of these guidelines was published last April, when we were finalising our letter; it does not support the theory of candidal overgrowth or the use of colonic cleansing and provides a critical appraisal of treatments. We are sure, however, that Shepherd agrees that there is an extensive literature on this emotive subject, not all of which has a firm scientific basis. The literature that we quoted had been obtained by
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