Letters
Preventing local complications of depot neuroleptics
EDITOR,--Justin Hay's short report on complications at the site of injection of depot neuroleptics raises an important issue affecting those patients who require maintenance treatment with such formulations.1 His conclusion that patients who have developed such complications should avoid certain formulations, including zuclopenthixol concentrate, is not borne out by our experience, both in clinical trials and from spontaneous reports of adverse reactions to the company. Certain aspects of Hay's study may go some way towards explaining this discrepancy.
Firstly, skill in giving depot injections may have varied widely among the health professionals involved in the study, and, additionally, no attempt seems to have been made to ensure standardisation of the injection technique (such as use of a Z track injection technique2 and rotation of injection sites). The 19 acute problems described as clinically important leakage from the injection site may therefore reflect poor injection technique. Similarly, the 52 acute problems
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- Complications at site of injection of depot neuroleptics
- Justin Hay
BMJ 1995 311: 421.[Full Text]
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