Prevention of diabetes

doi:10.1136/bmj.38996.709340.BE

BMJ 2006;333:764-765 (14 October), doi:10.1136/bmj.38996.709340.BE

Editorial

Prevention of diabetes

Drug trials show promising results, but have limitations

The first 150 words of the full text of this article appear below.

Diabetes affects one in 20 adults worldwide and 333 millioncases are projected worldwide by 2025.¹ Treatment can preventsome of the microvascular and macrovascular complications, butdiagnosis is often delayed until complications present,² soattention has focused on prevention and early screening. Twostrategies currently exist for reducing the onset of diabetes—lifestyleinterventions and drugs.

The Diabetes Prevention Program Research Group study found thatlifestyle interventions delivered over 2.8 years reduced theincidence of diabetes by 58%.³ A similar reduction in risk wasfound in a Finnish study of 522 people at risk.⁴ The problemis that these interventions are labour intensive—one studyneeded 16 one to one sessions delivered by case managers toachieve target weight reduction and exercise levels.³ Althoughlifestyle interventions produce successful results in researchsettings, they are difficult to replicate even in well fundedhealthcare systems.

Considerable interest has focused on the prevention . . . [Full text of this article]

Carl Heneghan, deputy director

Centre for Evidence Based Medicine, Department of Primary Health Care, University of Oxford, Oxford OX3 7LF
(carl.heneghan@dphpc.ox.ac.uk)

M Thompson, clinical lecturer, R Perera, senior statistician

Centre for Evidence Based Medicine, Department of Primary Health Care, University of Oxford, Oxford OX3 7LF

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