Prothrombotic condition combined with pill use increases risk of cerebral sinus thrombosis

Women who use oral contraceptives and carry a hereditary prothrombotic deficiency have an increased risk of deep vein thrombosis. On p 589 de Bruijn et al compared 40 women with cerebral sinus thrombosis with population data from the Netherlands. Prevalences of current use of oral contraceptives and the presence of a prothrombotic factor (protein C, S, or antithrombin deficiency or factor V Leiden mutation) were compared and odds ratios calculated. The age adjusted odds ratio for the association of sinus thrombosis with the use of oral contraceptives was 13 but became about 30 in the presence of a hereditary deficiency. This result does not justify negative advice about oral contraceptives, however, as the risk of cerebral sinus thrombosis is small.


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Relevant Article

Case-control study of risk of cerebral sinus thrombosis in oral contraceptive users who are carriers of hereditary prothrombotic conditions
S F T M de Bruijn, J Stam, M M W Koopman, and J P Vandenbroucke
BMJ 1998 316: 589-592. [Abstract] [Full Text] [PDF]

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