Daily progestogen protects the endometrium

Hormone replacement therapies that include continuous progestogen are associated with less endometrial damage, when used long term, than sequential oestrogen-progestogen regimens. A prospective study by Wells and colleagues (p 239) found no cases of endometrial hyperplasia or malignancy in women taking combined therapy. Continuous daily progestogen, the authors say, seems to keep the endometrium normal and correct hyperplasia that may develop during standard sequential regimens.


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Relevant Article

Effect on endometrium of long term treatment with continuous combined oestrogen-progestogen replacement therapy: follow up study
Michael Wells, David W Sturdee, David H Barlow, Lian G Ulrich, Karen O'Brien, Michael J Campbell, Martin P Vessey, and Anthony J Bragg
BMJ 2002 325: 239. [Abstract] [Full Text] [PDF]

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