Patients with hyperlipidaemia respond poorly to aspirin

Platelet responsiveness to aspirin in patients with hyperlipidaemia is reduced. Friend and colleagues (p 82) measured cholesterol concentrations and platelet aggregation in 56 consecutive patients who were receiving daily aspirin. Poor platelet responsiveness to aspirin occurred in over two thirds of patients with hyperlipidaemia. This group of patients may need higher doses of aspirin, alternative antiplatelet agents, or lower target concentrations for total cholesterol and low density lipoprotein cholesterol.


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Relevant Article

Research pointers: Platelet responsiveness to aspirin in patients with hyperlipidaemia
Maribeth Friend, Ivana Vucenik, and Michael Miller
BMJ 2003 326: 82-83. [Extract] [Full Text] [PDF]




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