Evidence for lowering LDL cholesterol in diabetes is lacking

Recommendations to reduce low density lipoprotein cholesterol concentrations to reduce cardiovascular risk in diabetic patients without coronary heart disease do not reflect the uncertainty in the evidence. A systematic review by Gami and colleagues (p 528) found that diabetic patients were excluded from many trials of primary prevention of cardiovascular disease, or relevant outcomes were not reported separately. The authors conclude that there is insufficient evidence to determine the safest way to reduce LDL cholesterolor whether this is the correct goal in diabetic patients without coronary heart disease.

(Credit: JOHN BAVOSI/SPL)

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Relevant Article

Systematic review of lipid lowering for primary prevention of coronary heart disease in diabetes

Apoor S Gami, Victor M Montori, Patricia J Erwin, Mehmood A Khan, and Steven A Smith
BMJ 2003 326: 528-529. [Extract] [Full Text] [PDF]