BMJ  2003;327 (19 July), doi:10.1136/bmj.327.7407.0-b

Alzheimer's disease may be prevented with NSAIDs

Non-steroidal anti-inflammatory drugs may prevent the development of Alzheimer's disease, though aspirin has only a modest preventive effect. In a meta-analysis, Etminan and colleagues (p 128) analysed data from nine observational studies with almost 15 000 participants who had used NSAIDs. The risk of developing Alzheimer's disease was reduced by about 30%. The benefit with aspirin was 13%. In addition, long term users of NSAIDs had a greater benefit than intermediate term users. The appropriate dose, duration, and ratios of risk to benefit are still unclear. The authors say that routine use of NSAIDs is not recommended until results from ongoing randomised controlled trials become available.

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Relevant Article

Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies

Mahyar Etminan, Sudeep Gill, and Ali Samii
BMJ 2003 327: 128. [Abstract] [Full Text] [PDF]