BMJ  2004;328:474-475 (28 February), doi:10.1136/bmj.328.7438.474

Editorial

Why do doctors use treatments that do not work?

For many reasons—including their inability to stand idle and do nothing

One of the surprising things about James Lind's celebrated trial of citrus fruit for scurvy was not just that he ignored the evidence from his own trial but that in clinical practice he continued to advocate treatments that he himself had found ineffective, including those containing sulphuric acid.^w1 The history of medicine is replete with examples of treatments once common practice but now known not to work—or worse, cause harm. Only because the French surgeon Paré ran out of boiling oil did he discover that not cauterising gun shot wounds with it created much less pain and suffering.^w2 Leeches and blood letting were used for thousands of years for almost everything. Attempts to show that they were ineffective were resisted with great passion by the medical profession.^w3 More recently, we have had treatment with insulin for schizophrenia and vitamin K for myocardial infarction.^{1 2} In case we are all feeling too smug about silliness in the bad old days, we have the recent crisis on finding that hormone replacement therapy does not prevent cardiovascular disease.³ Why do we still use ineffective treatments?

One reason is that our expectations for the benefits of treatment are too high. As Voltaire said, "The art of medicine consists in amusing the patient while nature cures the disease." Or, in modern parlance: most drugs work in only 30% or 50% of people.⁴ Because patients so often get better or worse on their own, no matter what we do, clinical experience is a poor judge of what does and does not work. Hence the need for adequately powered randomised controlled trials.

A second reason is we are taught that because medicine is based on the sciences, understanding the pathophysiology of disease is essential to effective treatment. And so it is for many treatments. Use of insulin for diabetic coma needs a full understanding of the pathophysiology. Similarly, our appreciation of how parachutes slow falls means we do not need a placebo controlled trial of parachutes.⁵ But we have many examples where this approach, without empirical testing, is wrong. Until recently, medical students were taught the pathophysiological reasons why blockers are contra-indicated in heart failure (they are a good treatment for heart failure); why colloid is more effective than crystalloid for fluid replacement (it is worse); and that because the vascular supply of the scaphoid places it at risk of non-union, any suspected fracture requires a cast (active mobilisation results in better outcomes).^{6 7} Lind's belief in the humoral basis of disease caused his resistance to his own trial evidence, and the medical profession to reject Louis's data on blood letting.^w4

Even when empiricism is satisfied we can be misled by looking at the wrong outcome. Fluoride increases bone density. But it also increases the fracture rate.⁸ Flecainide for the treatment of supraventricular tachycardia makes the electrocardiogram look normal, but only after clinical trials (that some thought unethical) did it emerge that it increases mortality.⁹

Some treatments have harms that outweigh their benefits and are not evident in trials. It was only after licensing in the United States and postmarketing surveillance that troglitazone was found to cause liver failure and had to be withdrawn.^w5

Reasons for using ineffective or harmful treatments Clinical experience Over-reliance on a surrogate outcome Natural history of the illness Love of the pathophysiological model (that is wrong) Ritual and mystique A need to do something No one asks the question Patients' expectations (real or assumed)

Let us not stop at ineffective treatments. Much of the clinical examination and diagnostic testing is more of a ritual than diagnostically useful. We continue to order routine blood tests before surgery without controlled trials to show benefit, and several case series that show that these tests rarely change outcomes or even management.¹⁰ Alternatively, what was once perhaps useful is now superseded by better investigation. When did whispering pectoriloquy last clinch a diagnosis of pneumonia?

Clinicians want to relieve suffering. We find it difficult to do nothing (the aphorism "Don't just do something, stand there!" seems ludicrous). So we send in the counselling teams after psychological trauma, probably making things worse.¹¹ Perhaps it is societal opinion (for which one ear of the medical profession is always pricked) that errors of omission are more reprehensible than errors of commission that is at fault. Is missing a rare diagnosis so much worse than harm from over-testing?¹²

What hope is there for not using treatments and tests that don't work? Medicine is not just a science—it is a human activity. It entails ritual, custom, and the expectations of doctors, patients, and society. To safeguard against ineffective or harmful health care we need doctors who want to do the best they can for their patients, who are willing to continually question their own managements, and who have readily available sources of information about what does work.

(j.doust{at}sph.uq.edu.au), Centre for General Practice, University of Queensland, Medical School, Herston, Queensland 4006, Australia

Centre for General Practice, University of Queensland, Medical School, Herston, Queensland 4006, Australia

---

Additional references w1-w5 are on bmj.com

Competing interests: None declared.

References

1. Jones K. Insulin coma therapy in schizophrenia. J R Soc Med 2000;93: 147-9.[Free Full Text]
2. Wasserman AJ, Gutterman LA, Yoe KB, Kemp VE Jr, Richardson DW. Anticoagulants in acute myocardial infarction. The failure of anticoagulants to alter mortality in a randomized series. Am Heart J 1966;71: 43-9.[CrossRef][Web of Science][Medline]
3. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women's health initiative randomized controlled trial. JAMA 2002;288: 321-33.[Abstract/Free Full Text]
4. Connor S. Glaxo chief: our drugs do not work on most patients. Independent 2003 Dec 8: 1.
5. Smith GC, Pell JP. Parachute use to prevent death and major trauma related to gravitational challenge: systematic review of randomised controlled trials. BMJ 2003;327: 1459-61.[Abstract/Free Full Text]
6. Sjolin SU, Andersen JC. Clinical fracture of the carpal scaphoid—supportive bandage or plaster cast immobilization? J Hand Surg Br 1988;13: 75-6.[CrossRef][Medline]
7. Clay NR, Dias JJ, Costigan PS, Gregg PJ, Barton NJ. Need the thumb be immobilised in scaphoid fractures? A randomised prospective trial. J Bone Joint Surg Br 1991;73: 828-32.
8. Haguenauer D, Welch V, Shea B, Tugwell P, Wells G. Fluoride for treating postmenopausal osteoporosis. Cochrane Database Syst Rev 2003;(4): CD002825 [GenBank] .
9. Echt DS, Liebson PR, Mitchell LB, Peters RW, Obias-Manno D, Barker AH, et al. Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The cardiac arrhythmia suppression trial. N Engl J Med 1991;324: 781-8.[Abstract]
10. Munro J, Booth A, Nicholl J. Routine preoperative testing: a systematic review of the evidence. Health Technol Assess 1997;1: 1-62.
11. Hobbs M, Mayou R, Harrison B, Worlock P. A randomised controlled trial of psychological debriefing for victims of road traffic accidents. BMJ 1996;313: 1438-9.[Free Full Text]
12. Feinstein AR. The "chagrin factor" and qualitative decision analysis. Arch Intern Med 1985;145: 1257-9.[Abstract/Free Full Text]

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