BMJ 2005;331 (17 December), doi:10.1136/bmj.331.7530.0
Dose of vitamin A could be halved
The dose of vitamin A that the World Health Organization currently recommends as routine food supplementation for children in low income countries could safely be halved. Stabell Benn and colleagues (p 1428) randomised nearly 5000 children aged 6 months to 5 years to the recommended dose or half of it. After nine months, mortality in children who received a lower dose was lower than in those who received the whole dose, as was hospital case fatality in girls (but not boys). However, in children aged 6-18 months the lower dose was associated with slightly higher morbidity.
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Credit: ADRIAN ARBIB/STILL PICTURES
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- Randomised study of effect of different doses of vitamin A on childhood morbidity and mortality
- Christine Stabell Benn, Cesario Martins, Amabelia Rodrigues, Henrik Jensen, Ida Maria Lisse, and Peter Aaby
BMJ 2005 331: 1428-1432.[Abstract] [Full Text] [PDF]
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