BMJ  2006;332 (21 January), doi:10.1136/bmj.332.7534.0-d

Oncolytic gene therapy is not innocuous

Although gene therapy has huge potential for many conditions, especially cancer, enthusiasm must not cloud judgment about the dangers for patients and for the population of using increasingly diverse, yet relatively untested, replicating oncolytic viruses as vectors for delivery of new genes, argue Chernajovsky and colleagues on page 170. They call for specific guidelines to cover the clinical application of oncolytic viruses (particularly if viruses are genetically modified) at local and international levels and for discussion about how preclinical testing for safety should be carried out.

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Relevant Article

Fighting cancer with oncolytic viruses

Yuti Chernajovsky, Lorna Layward, and Nicholas Lemoine
BMJ 2006 332: 170-172. [Full Text] [PDF]