BMJ  2006;332 (3 June), doi:10.1136/bmj.332.7553.0-b

COX 2 inhibitors and some NSAIDs increase the risk of vascular events

Use of selective COX 2 inhibitors is associated with a 1.4-fold increase in the risk of myocardial infarction, stroke, or vascular death compared with placebo; large doses of diclofenac and ibuprofen are also associated with an increased risk, whereas large doses of naproxen are not. In a meta-analysis of 138 randomised trials and almost 150 000 participants, Kearney and colleagues (p 1302) didn't have enough data to adequately assess whether the excess risk was dose dependent, but the hazard was not confined to long term use only.

Credit: MOTTA/MACCHIAVELLINI/NOTTOLA/SPL

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

Relevant Article

Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials

Patricia M Kearney, Colin Baigent, Jon Godwin, Heather Halls, Jonathan R Emberson, and Carlo Patrono
BMJ 2006 332: 1302-1308. [Abstract] [Full Text] [PDF]