BMJ  2006;332 (24 June), doi:10.1136/bmj.332.7556.0-b

Adding metformin doesn't increase number of ovulations in women with PCOS

Metformin does not increase the number of ovulations or pregnancies when added to clomifene citrate as first line treatment in infertile women with polycystic ovary syndrome (PCOS). Moll and colleagues (p 1485) allocated 228 such women to clomifene citrate plus metformin or clomifene citrate plus placebo. The ovulation rate in the metformin group was 64% and 72% in the placebo group. Rates of ongoing pregnancy or spontanteous abortion showed no significant differences, and a significantly larger proportion of women in the metformin group stopped treatment because of side effects.

Credit: NAJEEB LAYYOUS/SPL

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Relevant Article

Effect of clomifene citrate plus metformin and clomifene citrate plus placebo on induction of ovulation in women with newly diagnosed polycystic ovary syndrome: randomised double blind clinical trial

Etelka Moll, Patrick M M Bossuyt, Johanna C Korevaar, Cornelis B Lambalk, and Fulco van der Veen
BMJ 2006 332: 1485. [Abstract] [Full Text] [PDF]