BMJ  2006;333 (1 July), doi:10.1136/bmj.333.7557.0-b

Low cholesterol may not increase risk of stroke

High alcohol consumption may explain the association between low blood cholesterol and increased risk of haemorrhagic stroke. Ebrahim and colleagues (p 22) looked at cardiovascular risk factors and data of morbidity and mortality of > 750 000 Korean civil servants aged 30-64 over a time period of 11 years. Haemorrhagic stroke was negatively associated with blood cholesterol, but this inverse association was confined to participants with hypertension. When stratified by concentration of glutamyl transferase, the association was seen in participants with high concentrations of glutamyl transferase only.

Credit: GEOFF KIDD/SPL

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Serum cholesterol, haemorrhagic stroke, ischaemic stroke, and myocardial infarction: Korean national health system prospective cohort study

Shah Ebrahim, Joohon Sung, Yun-Mi Song, Robert L Ferrer, Debbie A Lawlor, and George Davey Smith
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