BMJ  2006;333 (30 September), doi:10.1136/bmj.333.7570.0-b

Congenital malformations may be linked to infertility

Children born to previously infertile couples, whether or not after infertility treatment, are more likely to have congenital malformations than children of fertile parents. Zhu and colleagues (p 679) conducted a large scale longitudinal study of three groups of liveborn children and their mothers—singletons and twins born of fertile couples and those born of previously infertile couples who either conceived naturally or after infertility treatment. Hormonal treatment for infertility seems to increase the risk of genital malformations, but this association, say the authors, may be confounded by the underlying reason for infertility.

Credit: MEDISCAN

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Relevant Article

Infertility, infertility treatment, and congenital malformations: Danish national birth cohort

Jin Liang Zhu, Olga Basso, Carsten Obel, Camilla Bille, and Jørn Olsen
BMJ 2006 333: 679. [Abstract] [Full Text] [PDF]